Early efforts from Spinazzola and Rrahmani earned a two-goal victory for the visitors at Lazio in a match marred by three dismissals.
This result moves Napoli to within a single point of Italian league pace-setters AC Milan, who won on Friday. Inter occupy third place but can return to the summit with a victory in their evening match.
Dominance Amid Absences
Hampered by the absence of a number of key personnel, Napoli commanded the game with patient build-up play. The opener came when Matteo Politano's cross was volleyed home by the wing-back at the far post.
The lead was extended in the first half as Rrahmani powered a glancing header from a Politano set-piece into the bottom corner. They came close to a third shortly after when Eljif Elmas saw his header crash against the woodwork.
Flashpoints and Dismissals
After the break brought further worry for the away side when a player was forced off. This incident triggered a short altercation, leading to yellow cards for a Napoli defender and Lazio's Tijjani Noslin—who subsequently received a second caution for a foul.
"I must congratulate the lads, playing with such a high standard of quality and physical strength without letting the opposition play is not easy," remarked the winning head coach. "We played at a very high level of play."
Tempers flared again near the end as players from both sides became involved in a fierce exchange, requiring the coach to step in. Both individuals were sent off for their involvement in the incident.
Other European Fixtures
In Spain's La Liga, Sevilla suffered a 3-0 defeat at home to lowly Levante. Levante established a lead with a well-worked move before scoring two more strikes in the second half to seal a convincing victory.
Meanwhile, Real Madrid face significant pressure when they welcome Betis, after their rivals extended their lead at the summit. In the day's other game, Atlético Madrid travel to face Real Sociedad.
In France, a historic Parisian clasico takes place as Paris FC face giants PSG. This match marks the first top-flight encounter between the two clubs in over 36 years, bringing significant spice to the occasion.
